For US residents only.

How to Take Treatment

Signifor® (pasireotide) Injection

Dosing and Administration

What does Signifor look like?

  • Signifor is a clear, colorless solution for injection in an ampule. Each ampule contains 1 mL of solution for injection
  • Signifor is available in doses of 0.3 mg, 0.6 mg, or 0.9 mg
  • Signifor is available in packs containing 60 ampules (10 packs of 6)
  • Signifor should be taken using sterile disposable syringes and injection needles

How do you use Signifor?

Signifor should be injected twice a day subcutaneously (into the fat just under the skin). Your doctor will prescribe the dose that is right for you. Your doctor will see how you respond to using Signifor, and may adjust the dose.

Tip: Using Signifor at the same time each day will help you remember when to use your medicine.

If this is your first time injecting a medicine, your health care team is there to help you. Your doctor should show you how to prepare and give your dose of Signifor before you use it for the first time. You should not inject Signifor until your doctor has shown you how to use it the right way.

What do I need?

To give yourself an injection, you will need:

  • 1 Signifor ampule
  • 1 sterile syringe
  • 1 long sterile needle to draw up the solution from the ampule (use only if instructed to do so by your doctor or nurse)
  • 1 short, fine sterile needle
  • Alcohol wipes
  • 1 cotton ball or gauze
  • A sharps disposal container or other closeable, puncture-resistant disposable container

The injection site

The injection site is the place on your body where you are going to inject the medicine. Signifor is intended for subcutaneous use. This means that it is injected through a short needle into the fat just under the skin. The thighs and the abdomen are the recommended areas for subcutaneous injection. Avoid soreness and skin irritation by choosing a different site from the previous one for each injection. Do not inject Signifor into the exact same spot for each injection. You should also avoid injections at sites that are sore or where the skin is red or irritated.

After injecting Signifor

  • Put your used needles and syringes in a US Food and Drug Administration (FDA)-cleared sharps disposal container right away after use. Do not throw away (dispose of) loose needles and syringes in your household trash
  • If you do not have an FDA-cleared sharps disposal container, you may use a household container that is:
    • Made of a heavy-duty plastic
    • Can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out
    • Upright and stable during use
    • Leak-resistant
    • Properly labeled to warn of hazardous waste inside the container
  • When your sharps disposal container is almost full, you will need to follow your community guidelines for the right way to dispose of your sharps disposal container. There may be state or local laws about how you should throw away used needles and syringes. For more information about safe sharps disposal, and for specific information about sharps disposal in the state you live in, go to the FDA’s website at

Try these strategies if you feel anxious about injecting

Try practicing deep breathing techniques to relax. Deep breathing is also referred to as diaphragmatic breathing because oxygen moving in and out of your lungs results from movement of your diaphragm and abdomen, not your chest. To experience how it works, place 1 hand on your chest and 1 hand on your abdomen and inhale and exhale until only the hand on your abdomen is moving up and down.

Try a technique called “reframing”—replacing negative thoughts with positive ones. For example, if you’re thinking, “The discomfort of these injections is another way Cushing’s disease is ruining my life,” you could change it to, “Taking this medicine is an important way for me to help manage Cushing’s disease.”

Know when to ask for help. Speak with your doctor or nurse if you have questions, problems, or concerns that are making it difficult to use Signifor as directed. The more you know about giving yourself injections, and the safety risks associated with them, the more confident you may feel.

Tips for a successful injection

  • Make sure to clean the injection area with an alcohol pad
  • Practice good injection technique. Gently pinch the skin at the injection site, and inject the needle at a 45-degree angle
  • The recommended injection sites for Signifor are the top of your thigh or stomach area (abdomen)
  • Rotate injection sites. Change your injection site in a regular pattern
  • Ask a family member or friend to assist with your injections if needed—or to just provide support
  • Keep your goal in mind. Remember why you’re taking Signifor to help put the need for injections in perspective

Rotating injection sites

The recommended areas to inject Signifor are the top of your thigh or stomach area (abdomen).

Change (rotate) your injection site with each dose. Do not inject Signifor into the exact same spot for each injection. Do not inject Signifor into skin that is red or irritated.

Traveling with Signifor

Take Signifor with you when needed so you can take your dose at the usual time. Protect your Signifor ampules by carrying them in a well-padded, insulated container to keep them at room temperature (store Signifor at 77°F; excursions permitted to 59°F to 86°F). Keep Signifor out of the light.

It can take time to become comfortable taking Signifor. Asking for support from a friend or family member is a good way to help you take Signifor.

Do not dispose of your used sharps disposal container in your household trash unless your community guidelines permit this. Do not recycle your used sharps disposal container.

Looking ahead

For many people, starting Signifor marks a key step in treating Cushing’s disease. During this time, remember the goal of Signifor therapy: to improve cortisol levels. So, it is important that you keep taking Signifor unless your doctor tells you to stop.

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