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How Treatment May Help

Signifor® (pasireotide) Injection

Treating Cushing’s Disease

If you have Cushing's disease, your doctor will work with you to create a plan to treat it. Together, you will talk about treatment options, goals, and other important steps, such as monitoring.
You need to start a treatment plan as soon as you've been diagnosed to avoid having high levels of cortisol for too long.

The goals of treating Cushing's disease include:

  • Lowering your cortisol levels to a normal level
  • Improving signs and symptoms you may be experiencing
  • Keeping your cortisol at a normal level for the long term, so that you don't experience a recurrence of Cushing's disease

Before starting treatment with Signifor

For many patients, starting Signifor is the first step of a long journey. To get started on the right foot, ask your doctor about any questions you might have. Before starting treatment, your doctor will measure your fasting plasma glucose, electrolyte levels, liver function, heart function (electrocardiogram), gall bladder function, and pituitary function.

Remember, reducing cortisol levels is the main goal when treating Cushing’s disease

Before starting Signifor, it is important to tell your doctor about your medical history and any medicines you’re taking.

Signifor may interact with other medicines

Taking Signifor with certain other medicines can affect how it works and cause side effects. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially if you take medicines:

  • To control your heart beat (anti-arrhythmics)
  • That can affect the electrical system of your heart (QT prolongation)
  • To control your blood pressure (such as beta-blockers or calcium channel blockers)
  • To control the electrolyte (such as potassium or magnesium) levels in your blood
  • Cyclosporine (Gengraf®, Neoral®, Restasis®, Sandimmune®)
  • Bromocriptine (Cycloset®, Parlodel®)

Ask your doctor for a list of these medicines, if you are not sure. To help prevent any interactions with Signifor, you should keep a list of the medicines you currently take to show your doctor and pharmacist when you get a new medicine.

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