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Monitoring Treatment

Signifor® (pasireotide) Injection

Monitor your cortisol levels

What is cortisol?

Cortisol is an important hormone. It's part of many processes in the body, including metabolism (the turning of food into energy) and your ability to fight infection.

The main goal of managing Cushing's disease is to control your cortisol levels and bring them back to within your goal range.

It is important to check your cortisol levels

Even after successful surgery, when cortisol levels return to normal, a tumor can grow back. In fact, 6 months after successful surgery to remove the tumor, nearly 1 out of every 5 patients had Cushing's disease return. The median time to the return of Cushing's disease for these patients was 39 months. Regular checking of your cortisol levels will help you and your doctor stay aware of any changes.

At a checkup, your doctor will measure your cortisol levels using 1 or more of these tests:

  • 1 mg dexamethasone suppression test, which measures if cortisol levels drop in your blood
  • A urinary free cortisol (UFC) test, which measures cortisol in the urine
  • A midnight plasma cortisol test, which measures cortisol levels in your blood at night
  • A late-night salivary cortisol test, which measures cortisol levels in your saliva

Your doctor might also measure your ACTH levels.

After you've been diagnosed with and treated for Cushing's disease, your doctor will recommend a plan of action. Following this plan, visiting your doctor regularly, and getting regular cortisol tests are important ways to control your condition.

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