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Understanding Side Effects

Signifor® (pasireotide) Injection

Focus on Possible Signifor Side Effects

There are certain things you can be ready for while you’re using Signifor, such as managing possible side effects. Be sure to talk with your doctor about potential side effects and what to do about them should you experience any.

If there are any questions about Signifor, please contact a PEAK pituitary care coordinator, at 1-877-503-3377, Monday–Friday (8 AM – 8 PM ET).

Signifor can cause serious side effects

  • Low cortisol levels in your blood (hypocortisolism). You may experience signs and symptoms of hypocortisolism, such as weakness, fatigue, loss of appetite, nausea, vomiting, low blood pressure, low level of sodium in your blood, or low blood sugar. Tell your doctor right away if you have any of these signs and symptoms because your doctor may change your dose of Signifor or ask you to stop taking it
  • High blood sugar (hyperglycemia). Signs and symptoms of hyperglycemia you may experience include excessive thirst, high urine output, increased appetite with weight loss, and tiredness. If you get hyperglycemia while taking Signifor, your doctor may give you another medicine to take to lower your blood sugar. Your doctor may also change your dose of Signifor or ask you to stop taking it
  • Slow heart rate (bradycardia). Signifor can cause your heart to beat slower, which may cause you to feel weak, dizzy, or even faint. People who have, or have had, heart problems are at higher risk for bradycardia
  • Problems with the electrical system of your heart (QT interval prolongation), which can put you at risk for abnormal heart beats, dizziness, and fainting spells that can be very serious. Call your doctor right away if you experience such spells
  • Elevation of your liver tests. Your doctor should do blood tests to monitor your liver tests while you use Signifor
  • Gallstones (cholelithiasis). Your doctor should do an ultrasound to check for gallstones before you start using Signifor and while you use it

Possible side effects of Signifor

The most common side effects of Signifor include:

  • Diarrhea
  • Nausea
  • High blood sugar
  • Headache
  • Abdominal pain
  • Fatigue
  • Diabetes mellitus
  • Gallstones
Understanding and Living with Cushing's Disease

Monitoring your blood sugar level

Your doctor should check your blood sugar level before you start taking Signifor and while you’re using it. Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Signifor. For more information, ask your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The Signifor Therapy Initiation Plan (TIP) is a great resource for your doctor or nurse. It can help them provide you with advice for managing certain side effects.

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